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1.

Oral Iptacopan Monotherapy in Paroxysmal Nocturnal Hemoglobinuria.

Peffault de Latour, Régis; Röth, Alexander; Kulasekararaj, Austin G; Han, Bing; Scheinberg, Phillip; Maciejewski, Jaroslaw P; Ueda, Yasutaka; de Castro, Carlos M; Di Bona, Eros; Fu, Rong; Zhang, Li; Griffin, Morag; Langemeijer, Saskia M C; Panse, Jens; Schrezenmeier, Hubert; Barcellini, Wilma; Mauad, Vitor A Q; Schafhausen, Philippe; Tavitian, Suzanne; Beggiato, Eloise; Chew, Lee Ping; Gaya, Anna; Huang, Wei-Han; Jang, Jun Ho; Kitawaki, Toshio; Kutlar, Abdullah; Notaro, Rosario; Pullarkat, Vinod; Schubert, Jörg; Terriou, Louis; Uchiyama, Michihiro; Wong Lee Lee, Lily; Yap, Eng-Soo; Sicre de Fontbrune, Flore; Marano, Luana; Alashkar, Ferras; Gandhi, Shreyans; Trikha, Roochi; Yang, Chen; Liu, Hui; Kelly, Richard J; Höchsmann, Britta; Kerloeguen, Cécile; Banerjee, Partha; Levitch, Rafael; Kumar, Rakesh; Wang, Zhixin; Thorburn, Christine; Maitra, Samopriyo; Li, Shujie.

N Engl J Med; 390(11): 994-1008, 2024 Mar 14.

Artículo en Inglés | MEDLINE | ID: mdl-38477987

2.

Development of a target concentration intervention to individualize paroxysmal nocturnal hemoglobinuria treatment with pegcetacoplan.

Ter Avest, Mendy; Langemeijer, Saskia M C; Blijlevens, Nicole M A; van de Kar, Nicole C A J; Ter Heine, Rob.

Ann Hematol; 2024 Mar 08.

Artículo en Inglés | MEDLINE | ID: mdl-38453703

3.

Erythroid predominance in bone marrow biopsies of AML patients after decitabine treatment correlates with mutation profile and complete remission.

Tiso, Francesca; Hebeda, Konnie M; Langemeijer, Saskia M C; de Graaf, Aniek O; Martens, Joost H A; Koorenhof-Scheele, Thessa N; Knops, Ruth; Kroeze, Leonie I; van der Reijden, Bert A; Jansen, Joop H.

Pathobiology; 2024 Apr 20.

Artículo en Inglés | MEDLINE | ID: mdl-38643752

4.

Nationwide study of eculizumab in paroxysmal nocturnal hemoglobinuria: Evaluation of treatment indications and outcomes.

Schaap, Charlotte C M; Heubel-Moenen, Floor C J I; Nur, Erfan; Bartels, Marije; van der Heijden, Olivier W H; de Jonge, Emiel; Preijers, Frank W M B; Blijlevens, Nicole M A; Langemeijer, Saskia M C.

Eur J Haematol; 110(6): 648-658, 2023 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-36811247

5.

Dose optimalization of subcutaneous ravulizumab is predicted to yield significant savings and to improve patient friendliness.

Ter Avest, Mendy; Langemeijer, Saskia M C; Blijlevens, Nicole M A; van de Kar, Nicole C A J; Ter Heine, Rob.

Br J Clin Pharmacol; 89(3): 1211-1215, 2023 03.

Artículo en Inglés | MEDLINE | ID: mdl-36394176

6.

The potential of individualized dosing of ravulizumab to improve patient-friendliness of paroxysmal nocturnal haemoglobinuria treatment at reduced costs.

Ter Avest, Mendy; Langemeijer, Saskia M C; Schols, Saskia E M; Burger, David M; van de Kar, Nicole C A J; Blijlevens, Nicole M A; Kievit, Wietske; Ter Heine, Rob.

Br J Clin Pharmacol; 87(8): 3359-3363, 2021 08.

Artículo en Inglés | MEDLINE | ID: mdl-33512711

7.

Clinical and biological impact of TET2 mutations and expression in younger adult AML patients treated within the EORTC/GIMEMA AML-12 clinical trial.

Aslanyan, Mariam G; Kroeze, Leonie I; Langemeijer, Saskia M C; Koorenhof-Scheele, Theresia N; Massop, Marion; van Hoogen, Patricia; Stevens-Linders, Ellen; van de Locht, Louis T; Tönnissen, Evelyn; van der Heijden, Adrian; da Silva-Coelho, Pedro; Cilloni, Daniela; Saglio, Giuseppe; Marie, Jean-Pierre; Tang, Ruoping; Labar, Boris; Amadori, Sergio; Muus, Petra; Willemze, Roel; Marijt, Erik W A; de Witte, Theo; van der Reijden, Bert A; Suciu, Stefan; Jansen, Joop H.

Ann Hematol; 93(8): 1401-12, 2014 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-24994606

8.

Proteinuria and Exposure to Eculizumab in Atypical Hemolytic Uremic Syndrome.

Ter Avest, Mendy; Steenbreker, Hilbert; Bouwmeester, Romy N; Duineveld, Caroline; Wijnsma, Kioa L; van den Heuvel, Lambertus P W J; Langemeijer, Saskia M C; Wetzels, Jack F M; van de Kar, Nicole C A J; Ter Heine, Rob.

Clin J Am Soc Nephrol; 18(6): 759-766, 2023 06 01.

Artículo en Inglés | MEDLINE | ID: mdl-36913245

9.

Anti Thymocyte Globulin-Based Treatment for Acquired Bone Marrow Failure in Adults.

Tjon, Jennifer M-L; Langemeijer, Saskia M C; Halkes, Constantijn J M.

Cells; 10(11)2021 10 27.

Artículo en Inglés | MEDLINE | ID: mdl-34831130

10.

Neutrophil specific granule and NETosis defects in gray platelet syndrome.

Aarts, Cathelijn E M; Downes, Kate; Hoogendijk, Arie J; Sprenkeler, Evelien G G; Gazendam, Roel P; Favier, Rémi; Favier, Marie; Tool, Anton T J; van Hamme, John L; Kostadima, Myrto A; Waller, Kate; Zieger, Barbara; van Bergen, Maaike G J M; Langemeijer, Saskia M C; van der Reijden, Bert A; Janssen, Hans; van den Berg, Timo K; van Bruggen, Robin; Meijer, Alexander B; Ouwehand, Willem H; Kuijpers, Taco W.

Blood Adv; 5(2): 549-564, 2021 01 26.

Artículo en Inglés | MEDLINE | ID: mdl-33496751

11.

Patient preferences and quality of life implications of ravulizumab (every 8 weeks) and eculizumab (every 2 weeks) for the treatment of paroxysmal nocturnal hemoglobinuria.

Peipert, John Devin; Kulasekararaj, Austin G; Gaya, Anna; Langemeijer, Saskia M C; Yount, Susan; Gonzalez-Fernandez, F Ataulfo; Ojeda Gutierrez, Emilio; Martens, Christa; Sparling, Amy; Webster, Kimberly A; Cella, David; Tomazos, Ioannis; Ogawa, Masayo; Piatek, Caroline I; Wells, Richard; Sicre de Fontbrune, Flore; Röth, Alexander; Mitchell, Lindsay; Hill, Anita; Kaiser, Karen.

PLoS One; 15(9): e0237497, 2020.

Artículo en Inglés | MEDLINE | ID: mdl-32886668

12.

Effect of Eculizumab on Iron Metabolism in Transfusion-independent Patients With Paroxysmal Nocturnal Hemoglobinuria.

Schaap, Charlotte C M; Schols, Saskia E M; Preijers, Frank W M B; de Jonge, Emiel; Laarakkers, Coby M M; Jansen, Joop H; Blijlevens, Nicole M A; Swinkels, Dorine W; Langemeijer, Saskia M C.

Hemasphere; 7(5): e878, 2023 May.

Artículo en Inglés | MEDLINE | ID: mdl-37092027

13.

Infections during eculizumab therapy in a Dutch population of patients with paroxysmal nocturnal haemoglobinuria.

Schaap, Charlotte C M; Grotens, Ayla; de Haan, Anton F J; Blijlevens, Nicole M A; Langemeijer, Saskia M C.

Clin Microbiol Infect; 27(10): 1534-1536, 2021 10.

Artículo en Inglés | MEDLINE | ID: mdl-34197930

14.

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes.

Nikoloski, Gorica; Langemeijer, Saskia M C; Kuiper, Roland P; Knops, Ruth; Massop, Marion; Tönnissen, Evelyn R L T M; van der Heijden, Adrian; Scheele, Theresia N; Vandenberghe, Peter; de Witte, Theo; van der Reijden, Bert A; Jansen, Joop H.

Nat Genet; 42(8): 665-7, 2010 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-20601954

15.

Acquired mutations in TET2 are common in myelodysplastic syndromes.

Langemeijer, Saskia M C; Kuiper, Roland P; Berends, Marieke; Knops, Ruth; Aslanyan, Mariam G; Massop, Marion; Stevens-Linders, Ellen; van Hoogen, Patricia; van Kessel, Ad Geurts; Raymakers, Reinier A P; Kamping, Eveline J; Verhoef, Gregor E; Verburgh, Estelle; Hagemeijer, Anne; Vandenberghe, Peter; de Witte, Theo; van der Reijden, Bert A; Jansen, Joop H.

Nat Genet; 41(7): 838-42, 2009 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-19483684

16.

TET proteins in malignant hematopoiesis.

Langemeijer, Saskia M C; Aslanyan, Mariam G; Jansen, Joop H.

Cell Cycle; 8(24): 4044-8, 2009 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-19923888

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